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KMID : 0385620150230010021
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Korean Journal of Psychopathology
2015 Volume.23 No. 1 p.21 ~ p.34
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Correlation of Cognitive Function and Homocysteine Levels in Old Schizophrenics
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Park Ji-Yong
Cheon Jin-Sook
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Abstract
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Objectives : The aims of this study were to identify the frequency of cognitive disorders and association with homocysteine levels in old age schizophrenics.
Methods : The data were obtained from admitted schizophrenics with age over 65 (N=108, male 59, female 49) by semistructured interviews and measurements of cognitive function using the MMSE and the MoCA-K, severity of psychosis using the K-PANSS and depression using the K-GDS.
Results : 1) The old age schizophrenics with increased homocysteine levels had significantly more males and longer duration of schizophrenia. 2) The frequency of cognitive disorder measured by the MMSE-K and the MoCA-K was 67.86% vs 96.43% in schizophrenics with normal homocysteine, and both 100% in schizophrenics with increased homocysteine. However, statistically significant difference was only found in those measured by the MMSE-K. 3) The total scores and subtests scores of the MMSE-K and the MoCA-K were significantly lower in old age scizophrenics with increased homocysteine levels. 4) The increase of homocysteine levels had significant negative correlation with total scores of the MMSE-K and subtests scores of time/place orientation, recall, languse and visuospatial function.
Conclusions : These findings suggest that increased homocysteine levels may be closely associated with pathogenesis of cognitive disorder in old age schizophrenics
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KEYWORD
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Old age schizophrenics, Increased homocysteine, Cognitive function, Orientation, Recall, Language/Visuospatial
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